ABSTRACT
Adult-onset Still's disease (AOSD) is a multi-systemic inflammatory disorder characterized by high spiking fever, evanescent salmon-colored rash, arthralgia or arthritis, leukocytosis and the involvement of various organs. However, leukopenia is rarely associated with AOSD. It may be due to hemophagocytic syndrome, which usually present with acute febrile illness, pancytopenia, hepatosplenomegaly, and hyperferritinemia. We report a case of 28-year-old man with AOSD and leukopenia. There is no evidence of other causes of cytopenia and hemophagocytosis in bone marrow examination. Leukopenia can be the initial presentation of AOSD.
Subject(s)
Adult , Humans , Arthralgia , Arthritis , Bone Marrow Examination , Exanthema , Fever , Leukocytosis , Leukopenia , Lymphohistiocytosis, Hemophagocytic , Pancytopenia , Still's Disease, Adult-OnsetABSTRACT
Dermatomyositis is a disease of non-pyogenic inflammation of skin and muscles in which tissues and cells are damaged by pathogenic autoantibodies and immune complexes. Diffuse subcutaneous and interstitial muscular calcinosis is well recognised and common in childhood dermatomyositis. However, soft tissue calcification in a patient with adult onset dermatomyositis has been rarely reported. We have experienced a patient with adult onset dermatomyositis who had diffuse subcutaneous tissue calcification on hands, arms, chest, abdomen and buttocks.
Subject(s)
Adult , Humans , Abdomen , Antigen-Antibody Complex , Arm , Autoantibodies , Buttocks , Calcinosis , Dermatomyositis , Hand , Inflammation , Muscles , Skin , Subcutaneous Tissue , ThoraxABSTRACT
Anaphylaxis is the most common systemic allergic reaction caused by bee stings. Delayed-type allergic reactions, including serum sickness, occur much less frequently. We report a 27-year-old man who developed serum sickness reaction nine days after multiple bee-stings. He had complained of erythematous skin rash, fever, arthralgia, myalgia and proteinuria. High specific IgE to bee venoms (honeybee, yellow jacket, yellow hornet) were observed by CAP system and C3, C4 and circulating immune complex levels measured by C1q binding assay showed normal values. We report a case of serum sickness reaction caused by multiple bee stings.
Subject(s)
Adult , Humans , Anaphylaxis , Antigen-Antibody Complex , Arthralgia , Bee Venoms , Bees , Bites and Stings , Exanthema , Fever , Hypersensitivity , Immunoglobulin E , Insect Bites and Stings , Myalgia , Proteinuria , Reference Values , Serum Sickness , WaspsABSTRACT
Human toxocariasis is defined as the infection of a human host by the larval stages of Toxocara canis, a common intestinal parasite of dogs. We experienced a patient with hypereosinophilic syndrome involving liver and stomach caused by human toxocariasis. The diagnosis of toxocariasis was confirmed by detecting serum specific IgE antibody to Toxocara excretory-secretory antigens (TES-Ag) by ELISA and IgG immunoblot analysis, with high sensitivity and specificity for the diagnosis of toxocariasis. Toxocariasis should be considered one of the causative diseases inducing hypereosinophilic syndrome in this country.